Drugs that should be avoided - Official List
这个列表有每种药的化学式.
Name | Molecular Formula | Risk Leve(Note[1]) | For Whom | Notes |
---|---|---|---|---|
Streptomycin | C21 H39 N7 O12 | Low | All | |
Colchicine | C22 H25 N O6 | Low | All | |
Mepacrine (Quinacrine) | C23 H3O Cl N3 O | High | Medit., Asian | |
Glucosulfone (glucosulfone sodium) | C24 H34 N2 Na2 O18 S3 | High | All | |
Doxorubicin | C27 H29 N O11 | High | Medit., Asian | |
Dimercaprol | C3 H8 O S2 | High | All | |
Phytomenadione (Vitamin K1) | C31 H46 O2 | Low | All | |
Glibenclamide | C32 H28 Cl N3 O5 S | High | Medit., Asian | Note[2] |
Isobutyl Nitrite | C4 H9 N O2 | High | Medit., Asian | |
Pamaquine | C42 H45 N3 O7 | High | All | |
Niridazole | C6 H6 N4 O3 S | High | All | |
Nitrofural (nitrofurazone) | C6 H6 N4 O4 | High | All | |
Isoniazid | C6 H7 N3 O | Low | All | |
Phynylhydrazine | C6 H8 N2 | High | All | |
Sulfanilamide (Sulphanilamide) | C6 H8 N2 O2 S | High | All | |
Ascorbic Acid | C6 H8 O6 | Low | All | |
Sulfaguanidine | C7 H10 N4 O2 S | Low | All | |
Trinitrotoluene (2,4,6-Trinitrotoluene) | C7 H5 N3 O6 | High | Medit., Asian | |
Para-Aminobenzoic Acid (4-Aminobenzoic Acid) | C7 H7 N O2 | Low | All | |
Mesalazine - 5-Aminosalicylic Acid (paraminosalicylic acid) | C7 H7 N O3 | High | Medit., Asian | |
Acetylphenylhydrazine (2-Phynylacetohydrazide) | C8 H10 N2 O | High | All | Note[3] |
Sulfacetamide | C8 H10 N2 O3 S | High | All | |
Dopamine (L-dopa) | C8 H11 N O2 | Low | All | |
Nitrofurantoin | C8 H6 N4 O5 | High | All | |
Furazolidone | C8 H7 N3 O5 | High | All | |
Acetanilide (acetanilid) | C8 H9 N O | High | Medit., Asian | |
Paracetamol (acetaminophen) | C8 H9 N O2 | Low | All | |
O-Acetylsalicylic Acid (acetylsalicylic acid) | C9 H8 O4 | High | Medit., Asian | Note[4] |
Thiazosulfone (thiazolesulfone) | C9 H9 N3 O2 S2 | High | Medit., Asian | |
metamizole | C13H16N3NaO4S | High | Medit., Asian | |
Arginine (acido 2(S)-ammino-5-guanidilpentanoico) | C6H14N4O2 | Low | ||
Brinzolamide | High | All | Note[5] | |
Dorzolamide | High | All | Note[6] | |
Oxidase, Urate (urate oxidase) | High | Medit., Asian | ||
Arsine | As-H3 | High | All | Note[7] |
Sulfadiazine | C10 H10 N4 O2 S | Low | All | |
Sulfamethoxazole | C10 H11 N3 O3 S | High | All | Note[8] |
Phenacetin (acetophenetidin) | C10 H13 N O2 | High | Medit., Asian | Note[9] |
Naphtalene, Pure (naphtalin) | C10 H8 | High | All | |
Beta-Naphthol (2-Naphthol) | C10 H8 O | High | All | |
Sulfapyridine | C11 H11 N3 O2 S | High | All | |
Phenazopyridine | C11 H11 N5 | High | Medit., Asian | |
Chloramphenicol | C11 H12 C12 N2 O5 | High | Medit., Asian | |
Phenazone (antipyrine) | C11 H12 N2 O | Low | All | |
Sulfamerazine | C11 H12 N4 O2 S | Low | All | |
Sulfamethoxypyridazine | C11 H12 N4 O3 S | Low | All | |
Sulfafurazole (sulfafurazone, sulfisoxazole) | C11 H13 N3 O3 S | High | Medit., Asian | |
Proguanil (chlorguanidine) | C11 H16 Cl N5 | Low | All | |
Menadiol Sodium Sulfate (Vitamin k4 sodium sulfate) | C11 H8 Na2 O8 S2 | High | All | Note[10] |
Menadione (menaphtone) | C11 H8 O2 | High | All | Note[11] |
Menadione sodium Bisulfite (Vitamin K3 sodium bisulfite) | C11 H8 O2 NaHSO3 | High | All | Note[12] |
Dapsone (diaphenylsulfone) | C12 H12 N2 O2 S | High | All | Note[13] |
Nalidixic Acid | C12 H12 N2 O3 | High | Medit., Asian | Note[14] |
Pyrimethamine | C12 H13 Cl N4 | Low | All | |
Sulfadimidine | C12 H14 N4 O2 S | High | All | |
Sulfacytine | C12 H14 N4 O3 S | Low | All | |
Stibophen (2-(2-Oxido-3,5-Disulphonatophenoxy)-1,3,2,Benzodioxastibole-4-6-Disulphonate) | C12 H4 Na5 O16 S4 Sb | High | All | |
Aminophenazone (aminopyrine) | C13 H17 N3 O | Low | All | |
Probenecid | C13 H19 NO4 S | High | All | |
Procainamide | C13 H21 N3 O | Low | All | |
Tiaprofenic Acid | C14 H12 O3 S | Low | All | |
Aldesulfone sodium (sulfoxone) | C14 H14 N2 Na2 O6 S3 | High | All | |
Trimethoprim | C14 H18 N4 O3 | Low | All | Note[15] |
Tolonium Chloride, Tolonium Chloride (toluidine blue) | C15 H16 Cl N3 S | High | All | |
Primaquine | C15 H21 N3 O | High | All | Note[16] |
Methyltioninium Chloride (methylene blue) | C16 H18 Cl N3 S | High | All | |
Norfloxacin | C16 H18 F N3 O3 | Low | All | |
Tripelennamine | C16 H21 N3 | Low | Medit., Asian | |
Ciprofloxacin | C17 H18 F N3 O3 | High | Medit., Asian | Note[17] |
Antazoline (antistine) | C17 H19 N3 | Low | All | |
Diphenhydramine (difenilhydramine) | C17 H21 N O | Low | All | |
Sulfasalazine, Salazosulfapyridine (salazopyrin) | C18 H14 N4 O5 S | High | All | |
Chloroquine | C18 H26 Cl N3 | High | Medit., Asian | Note[18] |
Pentaquine | C18 H27 N3 O | High | All | |
Phenylbutazone | C19 H20 N2 O2 | Low | All | |
Phenytoin | C19 H20 N2 O2 | Low | All | |
Quinidine | C20 H24 N2 O2 | Low | All | |
Quinine | C20 H24 N2 O2 | Low | All | |
Trihexyphynidyl (benzhexol) | C20 H31 N O | Low | All |
NOTE:
[1] Low risk means that for common G6PD deficiency variants these may be considered safe in most cases, when taken in normal therapeutic doses. However, they might provoke hemolysis when taken in large doses (accidental ingestion, poisoning, special treatments) or in the period preceding birth, or in presence of other pathologies.
[2] Hemolytic reactions to this substance have been reported only in few, isolated cases and no written reference exists as of this time.
[3] These substances taken in high quantities might cause hemolysis also with normal subjects.
[4] Among the alternatives are Paracetamol, which is generally considered safe, and flurbiprophene.
[5] See http://marineyes.com/glaucoma/medications.html
[6] See http://marineyes.com/glaucoma/medications.html
[7] These substances taken in high quantities might cause hemolysis also with normal subjects.
[8] A component, together with Trimetroprim, of Co-trimoxazole.
[9] Probably safe in moderate doses.
[10] Synthetic substitutes of natural Vitamin K. Other substitutes non listed here are: menadiole diacetate, menadiole sodium phosphate (anhydrous salt). As treatment of hemorrhage in newborns, a single dose of this substance may be given (via parenteral) on the first day after birth and is well tolerated. The writers of these note (2,16) generally consider all Vitamin K substitutes as potentially hemolysis inducing substances. It is probable that natural Vitamin K1 (phyto-menadione) presents a lower risk.
[11] Synthetic substitutes of natural Vitamin K. Other substitutes non listed here are: menadiole diacetate, menadiole sodium phosphate (anhydrous salt). As treatment of hemorrhage in newborns, a single dose of this substance may be given (via parenteral) on the first day after birth and is well tolerated. The writers of these note (2,16) generally consider all Vitamin K substitutes as potentially hemolysis inducing substances. It is probable that natural Vitamin K1 (phyto-menadione) presents a lower risk.
[12] Synthetic substitutes of natural Vitamin K. Other substitutes non listed here are: menadiole diacetate, menadiole sodium phosphate (anhydrous salt). As treatment of hemorrhage in newborns, a single dose of this substance may be given (via parenteral) on the first day after birth and is well tolerated. The writers of these note (2,16) generally consider all Vitamin K substitutes as potentially hemolysis inducing substances. It is probable that natural Vitamin K1 (phyto-menadione) presents a lower risk.
[13] These substances taken in high quantities might cause hemolysis also with normal subjects.
[14] Hemolytic reactions to this substance have been reported only in few, isolated cases and no written reference exists as of this time.
[15] Component, together with Sulfametossazole, of Co-trimoxazolo.
[16] May be given in reduces doses under medical supervision.
[17] Hemolytic reactions to this substance have been reported only in few, isolated cases and no written reference exists as of this time.
[18] If required, this substance may be taken under medical supervision as a preventive treatment or cure of malaria.
Miscellaneous elements besides drugs that should be avoided:
Fava Beans
(Some, but only some, prefer also to avoid red wine, henna (see below), all legumes, blueberries [also yogurts containing these], soya products, tonic water: whether you should avoid any of these would depend on your enzyme deficit level and mutation.)
Henna
Black Henna (Indigofera tinctoria), Red Egyptian Henna (Lawsonia inermis) and other related dyes, used for both tattoos and hair dyes. Ann Trop in Pediatr 16: 287, 1996 and Kök AN, Ertekin MV, Ertekin V, Avci B. in Int J Clin Pract 58: 530, 2004) have shown that henna might trigger in G6PD deficient persons hemolytic crisis or at least an excessive hemolysis.
In vitro experiments suggest that the substance responsible for such hemolysis is 2-hydroxy-1,4-naphthoquinone (or lawsone: see Pediatrcis 97:707,1996).
[Information generously offered to the Association by Prof. Lucio Luzzatto, Scientific Director at the Istituto Toscano Tumori, Firenze, Italy; Consultant at the Department of Human Genetics and Division of Hematologic Oncology at the Department of Medicine Memorial Hospital for Cancer and Allied Diseases at the Memorial Sloan Kettering Cancer Center, New York].
Glaucoma
Please note that the following medications often prescribed to fight glaucoma are contraindicated for persons suffering from G6PD deficiency:
Dorzolamide (trade name, Trusopt), Brinzolamide (Azopt) and Acetazolamide (Diamox pills).
For a detailed list of eye drops or pills that can and cannot be taken by G6PD deficient persons who suffer from glaucoma please see:
http://marineyes.com/glaucoma/medications.html.
需要避免的中药
牛黄
Cattle Gallstone Bezoar
(Bos Taurus Domesticus)
Cool.
Influences the heart and liver channels. Opens up the senses, dissolves phlegm, extinguishes wind, neutralizes fire-toxins and stops tremors.
Commonly used to treat fainting, mental disorders, convulsions, high fever and all forms of hot, red swellings
金银花
Honeysuckle
(Lonicera Japonica)
Cold.
Influences the large intestine, lung and stomach channels. Clears dampness in the lower body, relieves externally caused wind and clears fire toxicity.
Commonly used to treat painful urination, fever, sore throat, headache, sores, swellings and abcesses
腊梅花
Chimonanthus Flower
(Chimonanthus Praecox)
Neutral.
Influences the liver and lung channels. Neutralizes heat-toxins, clears phlegm and activates blood and circulation.
Commonly used to treat fever, sore throat and painful eye problems. Also used to clear the last stage of measles
黄莲/川莲
Huang Lian (黄连)
Mainly yielded in the province of Si Chuan (四川), therefore it’s also called Chuan Lian (川连). Bitter in flavour, cold in property. Acting on heart, stomach, liver & large intestine channels. It clears away heat, dries dampness, purges fire and clears toxins. Commonly used to treat diarrhea, high fever and suppurative infections of the damp-heat type.
[Courtesy of John Lew, Physician, Traditional Chinese Medicine, www.lews.info]
珍珠粉
100% Pearl Powder
Used to clear excess heat, settle the mind and frequent, fitful dreams. It can also be applied externally for mild acne and to promote a clear and clean complexion.